Infection a major clinical challenge

AMR: the problem worsens even further

Challenge of the biofilm on implant surfaces

Literature references

1. Hogan A et al. Osteomyelitis. Archives of Orthopaedic and Trauma Surgery, 2013 vol. 133, no. 9: 1183–1196.

2. Trampuz A. and Widmer AF. Infections associated with orthopedic implants. Current Opinion in Infectious Diseases, 2006 vol. 19, no. 4, pp. 349–356.

3. Esposito S, Noviello S, Leone S. Epidemiology and microbiology of skin and soft tissue infections. Curr Opin Infect Dis. 2016 Apr;29(2):109-15.

4. Parsons P. and Strauss E. Surgical management of chronic osteomyelitis. The American Journal of Surgery, 2004, vol. 188, no. 1, supplement 1, pp. 57–66.

5. Geurts J et al. Bone graft substitutes in active or suspected infection. Contraindicated or not?. Injury, 2011, vol. 42, supplement 2, pp. S82–S86.

6. Walenkamp GH et al. Gentamicin-PMMA beads. Pharmacokinetic and nephrotoxicological study Clinical Orthopaedics and Related Research, 1986, vol. 205, pp. 171–183.

7. Zhivich A. Fighting antimicrobial resistance: approaches, challenges, and opportunities in the search for new antibiotics. Mir journal 2017 Vol 4 (1):31-51.

8. Report: The evolving threat of antimicrobial resistance. Options for action. World Health Organization 2012. ISBN 978 92 4 150318 1.

9. Burnham JP, Olsen MA, Kollef MH. Re-estimating annual deaths due to multidrug-resistant organism infections. Infect Control Hosp Epidemiol. 2019 Jan;40(1):112-113.

10. Report: Annual epidemiological report antimicrobial resistance and healthcare-associated infections 2014. EARS-net. www.ecdc.europa.eu

11. Report: CDC. Antibiotic Use in the United States, 2017: Progress and Opportunities. Atlanta, GA: US Department of Health and Human Services, CDC; 2017.

12. O'Neill J. Review on Antimicrobial Resistance Antimicrobial Resistance: Tackling a crisis for the health and wealth of nations. London: Review on Antimicrobial Resistance; 2014.

13. Teillant A et al. Potential burden of antibiotic resistance on surgery and cancer chemotherapy antibiotic prophylaxis in the USA: A literature review and modeling study. Lancet Infect Dis 2015. 15(12): 1429-37

14. Report: Global action plan on antimicrobial resistance. World Health Organization 2015 ISBN 978 92 4 150976 3.

The DARTBAC project will prepare the Netherlands for the time when antibiotics are much less effective in the prevention and eradication of infection due to AntiMicrobial Resistance (AMR)
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